Undiagnosed acute viral febrile illnesses; Sierra Leone
Autor(es): Schoepp Randal J, Rossi Cynthia A, Khan Sheik H, Goba Augustine, Fair Joseph N
Resumo: Sierra Leone in West Africa is in a Lassa fever-hyperendemic region that also includes Guinea - Liberia. Each year, suspected Lassa fever cases result in submission of ?500-700 samples to the Kenema Government Hospital Lassa Diagnostic Laboratory in eastern Sierra Leone. Generally only 30%-40% of samples tested are positive for Lassa virus (LASV) antigen -/or LASV-specific IgM; thus, 60%-70% of these patients have acute diseases of unknown origin. To investigate what other arthropod-borne - hemorrhagic fever viral diseases might cause serious illness in this region - mimic Lassa fever, we tested patient serum samples that were negative for malaria parasites - LASV. Using IgM-capture ELISAs, we evaluated samples for antibodies to arthropod-borne - other hemorrhagic fever viruses. Approximately 25% of LASV-negative patients had IgM to dengue, West Nile, yellow fever, Rift Valley fever, chikungunya, Ebola, - Marburg viruses but not to Crimean-Congo hemorrhagic fever virus.
Palavras-Chave: ELISA; IgM; Lassa virus; Sierra Leone; West Africa; arthropod-borne; diagnostics; febrile; hemorrhagic fever; immunodiagnostics; serologic; undiagnosed; vector-borne infections; viruses
Imprenta: Emerging Infectious Diseases, v. 20, n. 7, p. 1176-1182, 2014
Identificador do objeto digital: 10.3201/eid2007.131265
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Immunology
Data de publicação: 2014
