Epidemiology of Guillain-Barré syndrome in the province of Quebec.

Autor(es): Deceuninck Geneviève; Boucher Renée-Myriam; De Wals Philippe; Ouakki Manale

Resumo: In the province of Quebec, a population-based study of Guillain-Barré syndrome (GBS) was conducted at the time of a mass immunization campaign against meningococcal disease, in 2001. The study population included residents aged 2 months to 20 years observed from November 1st, 2000 to December 31, 2002, representing 4,075,465 person-years of observation. GBS cases were identified in the provincial hospital database Med-Echo and medical records were reviewed. Thirty-three incident GBS cases were identified, including 27 cases of acute inflammatory demyelinating polyradiculopathy. The overall GBS incidence rate was 0.8/100,000 person-years, higher in persons aged 1 to 4 years (2.1/100,000) than in those 5 years or more (0.6/100,000). There was a female preponderance and no significant seasonal variation. All patients survived. Results could be used to interpret reports of adverse events associated with the introduction of new vaccines in this age-group in Canada.

Imprenta: The Canadian Journal of Neurological Sciences, v. 35, n. 4, p. 472-475, 2008

Identificador do objeto digital: 10.1017/S0317167100009136

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Vaccine ; Guillain-Barre Syndrome - Epidemiology ; Guillain-Barre Syndrome - Public health

Data de publicação: 2008