Range of cross reactivity of anti-GM1 IgG antibody in Guillain-Barré syndrome.
Autor(es): Koga M.; Tatsumoto M.; Yuki N.; Hirata K.
Resumo: The cross reactivity of anti-GM1 IgG antibody with various gangliosides and asialo-GM1 in serum samples from 27 patients with Guillain-Barré syndrome was investigated. An enzyme linked immunosorbent assay (ELISA) absorption study showed that anti-GM1 IgG antibody cross reacted with asialo-GM1 in 52% of the patients, GM1b in 41%, GD1b in 22%, and GalNAc-GD1a in 19%, and that it did not cross react with GM2, GT1b, or GQ1b. The antibody that cross reacted with GD1b was associated with a high frequency of cranial nerve involvement and negative Campylobacter jejuni serology. Anti-GM1 IgG antibody has a broad range of cross reactivity which may contribute to various clinical variations of Guillain-Barré syndrome.
Imprenta: Journal of Neurology, Neurosurgery, and Psychiatry, v. 71, n. 1, p. 123-124, 2001
Identificador do objeto digital: 10.1136/jnnp.71.1.123
Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Serology ; Guillain-Barre Syndrome - Immunology
Data de publicação: 2001
