Splenic rupture associated with primary CMV infection, AMSAN, and IVIG
Autor(es): de Havenon Adam,Davis Gary,Hoesch Robert
Resumo: Splenic rupture is a rare complication of primary cytomegalovirus infection, but has not been reported after administration of intravenous immunoglobulin or in the setting of the Guillain-Barré syndrome and its many variants, which often lead to treatment with intravenous immunoglobulin. There is strong evidence that intravenous immunoglobulin causes sequestration of erythrocytes in the spleen and extravascular hemolytic anemia. This may result in a two-hit scenario that clinicians should be aware of, where a patient who is at risk for splenic rupture due to primary cytomegalovirus infection receives intravenous immunoglobulin as treatment for the cytomegalovirus-associated Guillain-Barré syndrome, further increasing their risk of rupture.
Palavras-Chave: AMSAN; Cytomegalovirus; Guillain-Barré syndrome; Hemolysis; Intravenous immunoglobulin; Splenic rupture
Imprenta: Journal of Neuroimmunology, v. 272, n. 1-2, p. 103-105, 2014
Identificador do objeto digital: 10.1016/j.jneuroim.2014.05.004
Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Viral infections
Data de publicação: 2014
