Killer immunoglobulin-like receptor and their HLA ligands in Guillain-Barré Syndrome.
Autor(es): Blum Stefan; Csurhes Peter; Reddel Stephen; Spies Judy; McCombe Pamela
Resumo: Guillain-Barré Syndrome (GBS) is an inflammatory neuropathy that occurs in some individuals after exposure to an infectious illness. We investigated the role of Killer-immunoglobulin-like receptors (KIR) and their HLA ligands as potential genetic factors in the pathogenesis of GBS. These receptors are involved in the innate immune response to infections. Whilst no significant differences in the frequencies KIR genes were found, HLA-C2 and HLA-B Bw4-T were more frequent in subjects with GBS than controls (p<0.001). The inhibitory pairs KIR-2DL2/HLA-C2 and KIR-3DL1/HLA-B Bw4-T were more frequent in GBS than controls (all p<0.005). We propose that NK cell inhibition is an important factor in the pathogenesis of GBS.
Palavras-Chave: Gene frequency, Guillain-Barré syndrome, Histocompatibility antigens, Class I, Killer cells, Natural, Receptors, KIR
Imprenta: Journal of Neuroimmunology, v. 267, n. 1-2, p. 92-96, 2014
Identificador do objeto digital: 10.1016/j.jneuroim.2013.12.007
Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Immune response ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Public health
Data de publicação: 2014
