Utility of serum Campylobacter specific antibodies in determining prior Campylobacter infection in neurological disease
Autor(es): Taylor Bruce V,Williamson Jan,Jones David,Coleman David,Luck Jacquie,McGregor Alistair
Resumo: Campylobacter jejuni has been implicated in the pathogenesis of Guillain-Barre syndrome (GBS); however, little information exists on the utility of Campylobacter serology in determining recent infection in the patient population. C. jejuni specific antibodies (CAs) were measured in 420 blood donors (controls), 99 patients with recent C. jejuni infection, 34 patients with central nervous system disorders (neurology controls), and 44 patients with peripheral nervous system (PNS) disorders: 18 with GBS, 12 with MND and 14 with chronic inflammatory neuropathies. Elevated CA titres consistent with recent C. jejuni infection were found in six of the 44 patients with PNS disorders (three with GBS, two with neuropathy, and one with MND, only one of whom had a history of recent C. jejuni infection), compared with two of 454 controls (p = 0.00001). Therefore, we conclude that CAs are often raised in patients with PNS disorders who do not have a history of recent C. jejuni gastroenteritis, so Campylobacter serology may be an unreliable marker of recent infection in this patient group.
Palavras-Chave: Campylobacter jejuni; Guillain-Barre syndrome; Enzyme-linked immunosorbent assay; Motor neuron disease; Neuropathy
Imprenta: Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, v. 14, n. 2, p. 116-121, 2007
Identificador do objeto digital: 10.1016/j.jocn.2006.01.040
Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Serology ; Guillain-Barre Syndrome - Immunology ; Guillain-Barre Syndrome - Public health
Data de publicação: 2007
