Simultaneous Guillain-Barré syndrome and acute disseminated encephalomyelitis in the pediatric population
Autor(es): Bernard Geneviève,Riou Emilie,Rosenblatt Bernard,Dilenge Marie-Emmanuelle,Poulin Chantal
Resumo: Few cases of simultaneous acute demyelination of the peripheral and central nervous systems are reported. Four patients diagnosed as having Guillain-Barré syndrome and acute disseminated encephalomyelitis during the same hospitalization are described herein. Two patients manifest an atypical form of Guillain-Barré syndrome, with magnetic resonance imaging of the head showing acute disseminated encephalomyelitis. A third patient has acute disseminated encephalomyelitis and develops Guillain-Barré syndrome during his hospitalization. A fourth patient demonstrates transverse myelitis that evolves into Guillain-Barré syndrome, with demyelination seen on brain magnetic resonance imaging. All patients are treated with intravenous immunoglobulins or corticosteroids. Three patients have a favorable outcome; 1 patient has a chronic inflammatory demyelinating polyradiculoneuropathy. Guillain-Barré syndrome and acute disseminated encephalomyelitis can occur simultaneously in the pediatric population. This may be explained by a shared epitope between peripheral and central nervous system myelin. Further research is necessary to better describe this entity and its prognosis.
Palavras-Chave: Demyelination; Guillain-Barré syndrome; Inflammatory demyelinating polyradiculoneuropathy; Acute disseminated encephalomyelitis
Imprenta: Journal of Child Neurology, v. 23, n. 7, p. 752-757, 2008
Identificador do objeto digital: 10.1177/0883073808314360
Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies
Data de publicação: 2008
