The sera from GM1 ganglioside antibody positive patients with Guillain-Barré syndrome or chronic inflammatory demyelinating polyneuropathy blocks Na+ currents in rat single myelinated nerve fibers
Autor(es): Takigawa T,Yasuda H,Terada M,Haneda M,Kashiwagi A,Saito T,Saida T,Kitasato H,Kikkawa R
Resumo: To determine the possible role of anti-GM1 ganglioside antisera from patients with Gullain-Barr*e syndrome (GBS) or chronic inflammatory demyelinating polyneuropathy (CIDP) in the development of nerve dysfunction. The effect of the anti-GM1 antibody positive antisera obtained from 4 GBS patients and 1 CIDP patient on membrane potential and ionic currents in rat single myelinated nerve fibers was investigated using the voltage clamp technique and compared with that of the anti-GM1 negative antisera obtained from 3 healthy controls and 2 GBS patients. In the presence of active complement, anti-GM1 positive antisera from 5 patients including 4 GBS patients and 1 CIDP patient significantly suppressed Na+ current more than anti-GM1 negative antisera. This study supports the notion that anti-GM1 antibody is one of the causative factors of conduction abnormality in GBS patients.
Palavras-Chave: Anti-GM1 antibody; Inflammatory polyneuropathy; Ionic currents; Voltage clamp; Single fiber
Imprenta: Internal Medicine (Tokyo, Japan), v. 39, n. 2, p. 123-127, 2000
Identificador do objeto digital: 10.2169/internalmedicine.39.123
Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology
Data de publicação: 2000
