The role of innate versus adaptive immune responses in a mouse model of O'nyong-nyong virus infection
Autor(es): Seymour Robert L, Rossi Shannan L, Bergren Nicholas A, Plante Kenneth S, Weaver Scott C
Resumo: O'nyong-nyong virus (ONNV), an alphavirus closely related to chikungunya virus (CHIKV), has caused three major epidemics in Africa since 1959. Both ONNV - CHIKV produce similar syndromes with fever, rash, - debilitating arthralgia. To determine the roles of the innate - adaptive immune responses, we infected different knockout mice with two strains of ONNV (SG650 - MP30). Wild-type, RAG1 KO, - IFN?R KO mice showed no signs of illness or viremia. The STAT1 KO - A129 mice exhibited 50-55% mortality when infected with SG650. Strain SG650 was more virulent in the STAT1 KO - A129 than MP30. Deficiency in interferon ?/? signaling (A129 - STAT1 KO) leaves mice susceptible to lethal disease; whereas a deficiency of interferon ? signaling alone had no effect on survival. Our findings highlight the importance of type I interferon in protection against ONNV infection, whereas the adaptive immune system is relatively unimportant in the acute infection.
Imprenta: The American Journal of Tropical Medicine and Hygiene, v. 88, n. 6, p. 1170-1179, 2013
Identificador do objeto digital: 10.4269/ajtmh.12-0674
Descritores: Chikungunya virus - Cell ; Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Cytokines ; Chikungunya virus - Inflammation ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Immunology ; Chikungunya virus - Public health
Data de publicação: 2013
