Autor(es)Seymour Robert L, Rossi Shannan L, Bergren Nicholas A, Plante Kenneth S, Weaver Scott C

ResumoO'nyong-nyong virus (ONNV), an alphavirus closely related to chikungunya virus (CHIKV), has caused three major epidemics in Africa since 1959. Both ONNV - CHIKV produce similar syndromes with fever, rash, - debilitating arthralgia. To determine the roles of the innate - adaptive immune responses, we infected different knockout mice with two strains of ONNV (SG650 - MP30). Wild-type, RAG1 KO, - IFN?R KO mice showed no signs of illness or viremia. The STAT1 KO - A129 mice exhibited 50-55% mortality when infected with SG650. Strain SG650 was more virulent in the STAT1 KO - A129 than MP30. Deficiency in interferon ?/? signaling (A129 - STAT1 KO) leaves mice susceptible to lethal disease; whereas a deficiency of interferon ? signaling alone had no effect on survival. Our findings highlight the importance of type I interferon in protection against ONNV infection, whereas the adaptive immune system is relatively unimportant in the acute infection.

ImprentaThe American Journal of Tropical Medicine and Hygiene, v. 88, n. 6, p. 1170-1179, 2013

DescritoresChikungunya virus - Cell ; Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Cytokines ; Chikungunya virus - Inflammation ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Immunology ; Chikungunya virus - Public health

Data de Publicação:2013