Autor(es): Chevillon Christine, Briant Laurence, Renaud François, Devaux Christian

Resumo: Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus. Although primarily African - zoonotic, it is known chiefly for its non-African large urban outbreaks during which it is transmitted by the same vectors as those of Dengue viruses. Unlike Dengue viruses, CHIKV displays a re-emergence pattern that closely depends on long-distance migrations including recent re-immigrations from African (putatively zoonotic) sources. Genus-based differences also emerged when comparing the evolution of Dengue-related (Flaviviruses) - of CHIKV-related (Alphaviruses) arboviruses. In this review, we discuss current information on CHIKV genetics, ecology - human infection. Further investigations on African CHIKV ecology - the differences between Flavivirus - Alphavirus members in adaptive changes - evolutionary constraints are likely to help delineate the potential of further CHIKV (re-)emergence.

Imprenta: Trends in Microbiology, v. 16, n. 2, p. 80-88, 2008

Identificador do objeto digital: 10.1016/j.tim.2007.12.003

Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de publicação: 2008