Autor(es): Lemant Jérôme, Boisson Véronique, Winer Arnaud, Thibault Laure, André Hélène, Tixier François, Lemercier Marie, Antok Emmanuel, Cresta Marie Pierre, Grivard Philippe, Besnard Mathieu, Rollot Olivier, Favier François, Huerre Michel, Campinos José L, Michault Alain

Resumo: To report the clinical - laboratory findings of adults with serious chikungunya virus acute infection hospitalized in an intensive care unit. Case series study from August 2005 to May 2006. Medical intensive care unit, South Reunion Hospital. We observed 33 episodes of confirmed acute chikungunya virus infection (chikungunya virus-IgM or reverse transcription-polymerase chain reaction positive in the serum) admitted to the intensive care unit. We collected cerebrospinal fluid, serum, - sometimes tissue samples from patients with suspected chikungunya fever in our intensive care unit. These samples underwent viral testing for evidence of acute chikungunya virus infection. Of the 33 patients, 19 (58%) had chikungunya virus specific manifestations, 8 (24%) had associated acute infectious disease - 6 (18%) exacerbations of previous complaints. Among the chikungunya virus specific manifestations, we identified 14 cases of encephalopathy, one case each of myocarditis, hepatitis - Guillain Barré syndrome. Eighty-five percent of patients had a McCabe score = 1 (for nonfatal or no underlying disease). Mortality was 48%. Chikungunya virus infection may be responsible for very severe clinical presentation, including young patients with unremarkable medical histories. Chikungunya virus infection is strongly suspected to have neurologic, hepatic, - myocardial tropism leading to dramatic complications - high mortality rate.

Imprenta: Critical Care Medicine, v. 36, n. 9, p. 2536-2541, 2008

Identificador do objeto digital: 10.1097/CCM.0b013e318183f2d2

Descritores: Chikungunya virus - Viral infections ; Chikungunya virus - RT-PCR ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de publicação: 2008