Post-epidemic Chikungunya disease on Reunion Island: Course of rheumatic manifestations and associated factors over a 15-month period
Autor(es): Sissoko Daouda, Malvy Denis, Ezzedine Khaled, Renault Philippe, Moscetti Frederic, Ledrans Martine, Pierre Vincent
Resumo: Although the acute manifestations of Chikungunya virus (CHIKV) illness are well-documented, few data exist about the long-term rheumatic outcomes of CHIKV-infected patients. We undertook between June - September 2006 a retrospective cohort study aimed at assessing the course of late rheumatic manifestations - investigating potential risk factors associated with the persistence of these rheumatic manifestations over 15 months. 147 participants (>16 yrs) with laboratory-confirmed CHIKV disease diagnosed between March 1 - June 30, 2005, were identified through a surveillance database - interviewed by telephone. At the 15-month-period evaluation after diagnosis, 84 of 147 participants (57%) self-reported rheumatic symptoms. Of these 84 patients, 53 (63%) reported permanent trouble while 31 (37%) had recurrent symptoms. Age > or=45 years (OR = 3.9, 95% CI 1.7-9.7), severe initial joint pain (OR = 4.8, 95% CI 1.9-12.1), - presence of underlying osteoarthritis comorbidity (OR = 2.9, 95% CI 1.1-7.4) were predictors of nonrecovery. Our findings suggest that long-term CHIKV rheumatic manifestations seem to be a frequent underlying post-epidemic condition. Three independent risk factors that may aid in early recognition of patients with the highest risk of presenting prolonged CHIKV illness were identified. Such findings may be particularly useful in the development of future prevention - care strategies for this emerging virus infection.
Imprenta: PLoS Neglected Tropical Diseases, v. 3, n. 3, p. e389, 2009
Identificador do objeto digital: 10.1371/journal.pntd.0000389
Descritores: Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2009
