Autor(es): Robin Stéphanie, Ramful Duksha, Le Seach' Florence, Jaffar-B-jee Marie-Christine, Rigou Gérald, Alessandri Jean-Luc

Resumo: Chikungunya virus, a mosquito-borne arbovirus, was responsible for a massive epidemic in La Réunion Isl- during 2005 to 2006. The disease is usually benign, but neurologic involvement, with sometimes fatal outcome, has been described. We report a retrospective hospital-based pediatric series of 30 children (23 boys - 7 girls) who presented neurologic manifestations of chikungunya such as encephalitis (n = 12), febrile seizures (n = 10), meningeal syndrome (n = 4), - acute encephalopathy (n = 4). Cerebrospinal fluid biological - cytological analyses (n = 23) were unremarkable except for 1 case of acute disseminated encephalomyelitis. The presence of viral genome in cerebrospinal fluid was inconstantly positive. Brain magnetic resonance imaging (MRI) scans (n = 14) were abnormal in 5 cases. Electroencephalography was nonspecific. Two patients died. At discharge - 6 months later, 5 children had neurologic sequelae. Patients with initial severe neurologic presentation - having pathological brain MRI had more sequelae or fatal disease.

Imprenta: Journal of Child Neurology, v. 23, n. 9, p. 1028-1035, 2008

Identificador do objeto digital: 10.1177/0883073808314151

Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Cytopathology ; Chikungunya virus - Genome ; Chikungunya virus - Pathogenesis ; Chikungunya virus - RNA ; Chikungunya virus - Viral infections ; Chikungunya virus - RT-PCR ; Chikungunya Virus - Virus ; Chikungunya virus - Epidemic ; Chikungunya virus - Public health

Data de publicação: 2008

INDICADORES

ACESSO