Maiden outbreak of chikungunya in Dongguan city, Guangdong province, China: Epidemiological characteristics
Autor(es): Qiaoli Zhang, Jianfeng He, De Wu, Zijun Wang, Xinguang Zhong, Haojie Zhong, Fan Ding, Zhiquan Liu, Shiwen Wang, Zhenyu Huang, Yonghui Zhang, Changwen Ke, Dakang Yuan, Wenjia Liang, Deqiong Li, Pinghua Chen
Resumo: This study was conducted to identify epidemiological characteristics of the first documented CHIK fever outbreak in China - evaluate the effect of the preventive measures taken. From September 1 to October 29, 2010, China's first documented outbreak of CHIK fever occurred in the Xincun community of Wanjiang District of Dongguan city, Guangdong province; 253 case-patients were recorded, of which 129 were laboratory confirmed, with an attack rate of 1%. Before September 18(th) the number of CHIK fever cases remained relatively low in the Xincun community; from September 19(th) onwards, the number of cases increased drastically, with an outbreak peak on October 4(th). Cases were distributed across nine small village groups in the Xincun community, with an attack rate of 0-12% at the village level. The household attack rates ranged between 20% - 100%. No significant difference was found in the attack rate between males - females. There was a significant difference in the attack rate in different age groups (chi-square=18.35, p=0.005); highest in patients aged 60 years or older - the lowest in patients aged under 10. The major clinical characteristics of patients are fever (100%), joint pain (79%) - rash (54%). Phylogenetic analysis of the E1 gene on the five earliest confirmed cases showed that the strains of CHIKV isolated from their sera were highly homologous (up to 99%) with isogeneic strains isolated in Thail- in 2009. After control measures were taken, including killing adult mosquitoes - cleaning breeding habitats of Aedes mosquitoes, the Breteau index - Mosq-ovitrap index decreased rapidly, - the outbreak ended on October 29. The infection source of the outbreak was imported. Cases showed obvious temporal, spatial, - population aggregation during the outbreak. Comprehensive control measures based on reducing the density of Aedes mosquitoes were effective in controlling the epidemic.
Imprenta: PloS One, v. 7, n. 8, p. e42830, 2012
Identificador do objeto digital: 10.1371/journal.pone.0042830
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2012
