Autor(es)Kelvin Alyson A, Banner David, Silvi Giuliano, Moro Maria Luisa, Spataro Nadir, Gaibani Paolo, Cavrini Francesca, Pierro Anna, Rossini Giada, Cameron Mark J, Bermejo-Martin Jesus F, Paquette Stéphane G, Xu Luoling, Danesh Ali, Farooqui Amber, Borghetto Ilaria, Kelvin David J, Sambri Vittorio, Rubino Salvatore

ResumoThe Chikungunya virus infection zones have now quickly spread from Africa to parts of Asia, North America - Europe. Originally thought to trigger a disease of only mild symptoms, recently Chikungunya virus caused large-scale fatalities - widespread economic loss that was linked to recent virus genetic mutation - evolution. Due to the paucity of information on Chikungunya immunological progression, we investigated the serum levels of 13 cytokines/chemokines during the acute phase of Chikungunya disease - 6- - 12-month post-infection follow-up from patients of the Italian outbreak. We found that CXCL9/MIG, CCL2/MCP-1, IL-6 - CXCL10/IP-10 were significantly raised in the acute phase compared to follow-up samples. Furthermore, IL-1?, TNF-?, Il-12, IL-10, IFN-? - IL-5 had low initial acute phase levels that significantly increased at later time points. Analysis of symptom severity showed association with CXCL9/MIG, CXCL10/IP-10 - IgG levels. These data give insight into Chikungunya disease establishment - subsequent convalescence, which is imperative to the treatment - containment of this quickly evolving - frequently re-emerging disease.

ImprentaPLoS Neglected Tropical Diseases, v. 5, n. 8, p. e1279, 2011

DescritoresChikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Cytokines ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology ; Chikungunya virus - Public health

Data de Publicação:2011