Autor(es): Kelvin Alyson A, Banner David, Silvi Giuliano, Moro Maria Luisa, Spataro Nadir, Gaibani Paolo, Cavrini Francesca, Pierro Anna, Rossini Giada, Cameron Mark J, Bermejo-Martin Jesus F, Paquette Stéphane G, Xu Luoling, Danesh Ali, Farooqui Amber, Borghetto Ilaria, Kelvin David J, Sambri Vittorio, Rubino Salvatore

Resumo: The Chikungunya virus infection zones have now quickly spread from Africa to parts of Asia, North America - Europe. Originally thought to trigger a disease of only mild symptoms, recently Chikungunya virus caused large-scale fatalities - widespread economic loss that was linked to recent virus genetic mutation - evolution. Due to the paucity of information on Chikungunya immunological progression, we investigated the serum levels of 13 cytokines/chemokines during the acute phase of Chikungunya disease - 6- - 12-month post-infection follow-up from patients of the Italian outbreak. We found that CXCL9/MIG, CCL2/MCP-1, IL-6 - CXCL10/IP-10 were significantly raised in the acute phase compared to follow-up samples. Furthermore, IL-1?, TNF-?, Il-12, IL-10, IFN-? - IL-5 had low initial acute phase levels that significantly increased at later time points. Analysis of symptom severity showed association with CXCL9/MIG, CXCL10/IP-10 - IgG levels. These data give insight into Chikungunya disease establishment - subsequent convalescence, which is imperative to the treatment - containment of this quickly evolving - frequently re-emerging disease.

Imprenta: PLoS Neglected Tropical Diseases, v. 5, n. 8, p. e1279, 2011

Identificador do objeto digital: 10.1371/journal.pntd.0001279

Descritores: Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Cytokines ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology ; Chikungunya virus - Public health

Data de publicação: 2011

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