Heterologous activity of monkey interferons
Autor(es): Uhlendorf C P, Zimmerman E M, Baron S
Resumo: Interferon produced by cells of a given genus generally exerts antiviral activity best in cells of the same genus, partially in cells of closely related genera and rarely in distantly related genera. During a study of cell typing by interferons, it was observed that a preparation of monkey interferon as well as rat interferon strongly protected rat cells against vesicular stomatitis virus and Sindbis virus while human, mouse, and rabbit interferons provided no protection. Monkey interferons stimulated by several different viruses in African green monkey kidney cells protected several strains of rat cells. This heterologous antiviral activity was found to be (1) stable at pH 2, (2) inactivated by trypsin, (3) cell bound, (4) inhibited by actinomycin D but not by cycloheximide, (5) active against unrelated viruses, and (6) inactive on mouse and rabbit cells. The thermal lability curves were parallel when antiviral activity was assayed in homologous monkey cells or heterologous rat cells. The properties of the heterologously active antiviral material coincided with those of interferon.
Imprenta: Proceedings of the Society for Experimental Biology and Medicine, v. 144, n. 2, p. 628-632, 1973
Identificador do objeto digital: 10.3181/00379727-144-37650
Descritores: Chikungunya virus - Biosynthesis ; Chikungunya virus - Cell ; Chikungunya virus - Protein synthesis ; Chikungunya virus - Proteins ; Chikungunya virus - Cytokines ; Chikungunya virus - Serology ; Chikungunya virus - Serology ; Chikungunya Virus - Virus
Data de publicação: 1973
