Genomic evolution and phenotypic distinctions of Chikungunya viruses causing the Indian Ocean outbreak
Autor(es): Powers Ann M
Resumo: In our current global community with the rapid movement of products - people across - between continents, the emergence of a human pathogen can have devastating consequences. One dramatic example of this has been the emergence of Chikungunya virus (CHIKV), which causes a severe, prolonged, - debilitating arthralgic disease. This virus emerged in a large outbreak on the east coast of Africa in 2004; over the subsequent seven years, CHIKV has spread across the Indian Ocean, the Indian subcontinent, Southeast Asia - even reached Europe, leaving more than two million people affected. Because CHIKV has a small genome, currently available tools to analyze complete viral genomes have provided scientists with unique opportunities to underst- the epidemiology, pathogenesis - transmission of the virus. The most commonly used application of these cutting edge tools has been to track the movement of the virus over time - space. While this is an important concept for identifying areas that remain at risk for outbreaks, these postgenomic era tools can also be applied to the highly significant tasks of underst-ing how viral microevolutionary changes can affect both invertebrate transmission - vertebrate virulence. Significant alterations in the patterns of CHIKV movement have already been identified using microevolutionary studies. These approaches now need to be further exp-ed to aid in exp-ing vaccine, therapeutic - control options. This review will highlight some of the most significant recent research developments obtained using these cutting edge approaches for CHIKV.
Imprenta: Experimental Biology and Medicine, v. 236, n. 8, p. 909-914, 2011
Identificador do objeto digital: 10.1258/ebm.2011.011078
Descritores: Chikungunya virus - Genome ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Vaccine ; Chikungunya virus - Epidemiology
Data de publicação: 2011
