Entomologic and virologic investigation of Chikungunya, Singapore
Autor(es): Ng Lee-Ching, Tan Li-Kiang, Tan Cheong-Huat, Tan Sharon S Y, Hapuarachchi Hapuarachchige C, Pok Kwoon-Yong, Lai Yee-Ling, Lam-Phua Sai-Gek, Bucht Göran, Lin Raymond T P, Leo Yee-Sin, Tan Boon-Hian, Han Hwi-Kwang, Ooi Peng-Lim S, James Lyn, Khoo Seow-Poh
Resumo: Local transmission of chikungunya, a debilitating mosquito-borne viral disease, was first reported in Singapore in January 2008. After 3 months of absence, locally acquired Chikungunya cases resurfaced in May 2008, causing an outbreak that resulted in a total of 231 cases by September 2008. The circulating viruses were related to East, Central, - South African genotypes that emerged in the Indian Ocean region in 2005. The first local outbreak was due to a wild-type virus (alanine at codon 226 of the envelope 1 gene) - occurred in an area where Aedes aegypti mosquitoes were the primary vector. Strains isolated during subsequent outbreaks showed alanine to valine substitution (A226V) - largely spread in areas predominated by Ae. albopictus mosquitoes. These findings led to a revision of the current vector control strategy in Singapore. This report highlights the use of entomologic - virologic data to assist in the control of chikungunya in disease-endemic areas.
Imprenta: Emerging Infectious Diseases, v. 15, n. 8, p. 1243-1249, 2009
Identificador do objeto digital: 10.3201/eid1508.081486
Descritores: Chikungunya virus - Biochemistry ; Chikungunya virus - DNA ; Chikungunya virus - Genome ; Chikungunya virus - Molecular structure ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2009
