Effect of dibutyryl cyclic AMP on interferon production by cells treated with viral or nonviral inducers
Autor(es): Dianzani F, Neri P, Zucca M
Resumo: Treatment of mouse L or rat embryo cells with dibutyryl cyclic AMP prevents, or strongly reduces, the production of interferon induced either by poly I.poly C or by Newcastle disease and Chikungunya viruses. The same effect was also observed in cells treated with adrenaline plus theophylline (enhancers of cyclic AMP). In addition the inhibitory activity of dibutyryl cyclic AMP was prevented by suppression of protein synthesis with cycloheximide. Preliminary evidence obtained using metabolic inhibitors suggests that the depression of interferon production may be due to an effect at the transcriptional level. The results are interpreted to indicate a possible role of cyclic AMP on the intracellular regulatory mechanisms of the interferon system.
Imprenta: Proceedings of the Society for Experimental Biology and Medicine, v.140, n. 4, p. 1375-1378, 1972
Identificador do objeto digital: 10.3181/00379727-140-36677
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Biosynthesis ; Chikungunya virus - Cell ; Chikungunya virus - Protein synthesis ; Chikungunya virus - Proteins ; Chikungunya virus - Cytokines ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus
Data de publicação: 1972
