Current epidemiology and clinical practice in arboviral infections and implications on blood suply in South-East Asia
Autor(es): Gan V C H, Leo Y-S
Resumo: Arthropod-borne viruses (arboviruses) are a growing threat to global health. Complex vector-virus-host interactions lead to unpredictable epidemiological patterns. Difficulties in accurate surveillance including imperfect diagnostic tools impair effective response to outbreaks. With arboviral infections causing a wide spectrum of disease severity, from asymptomatic infection to fatal neuroinvasive - haemorrhagic fevers, the potential impact on blood safety is significant. Asymptomatic or presymptomatic individuals may introduce virus into the blood suply by donation, while recipients can potentially suffer severe consequences. Dengue, West Nile - chikungunya outbreaks have led to responses by blood transfusion services which can inform future planning. Reports of transfusion-associated transmission demonstrate the potentially fatal consequences of lack of haemovigilance. South-East Asia remains vulnerable to arboviruses with permissive climate - high levels of endemic transmission as well as the potential for emerging - re-emerging arboviral diseases. Resource limitations constrain the use of expensive technologies for donor screening. Continued surveillance - research will be required to manage the arboviral threat to the blood suply.
Palavras-Chave: NAT testing; Blood donation testing; Epidemiology; Pathogen inactivation; Transfusion-transmissible infections; Viral safety of plasma derivatives
Imprenta: ISBT Science Series, v. 9, n. 1, p. 262-267, 2014
Identificador do objeto digital: 10.1111/voxs.12083
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemiology
Data de publicação: 2014
