Autor(es): Gérardin Patrick, Couderc Thérèse, Bintner Marc, Tournebize Patrice, Renouil Michel, Lémant Jérome, Boisson Véronique, Borgherini Gianandrea, Staikowsky Frédérik, Schramm Frédéric, Lecuit Marc, Michault Alain

Resumo: To estimate the cumulative incidence rate (CIR) of Chikungunya virus (CHIKV)-associated CNS disease during the La Réunion outbreak, - assess the disease burden - patient outcome after 3 years. CHIKV-associated CNS disease was characterized retrospectively in a cohort of patients with positive CHIKV reverse transcriptase PCR or anti-CHIKV immunoglobulin M antibodies in the CSF - fulfilling International Encephalitis Consortium criteria for encephalitis or encephalopathy. Neurologic sequelae were assessed after 3 years. Between September 2005 - June 2006, 57 patients were diagnosed with CHIKV-associated CNS disease, including 24 with CHIKV-associated encephalitis, the latter corresponding to a CIR of 8.6 per 100,000 persons. Patients with encephalitis were observed at both extremes of age categories. CIR per 100,000 persons were 187 - 37 in patients below 1 year - over 65 years, respectively, both far superior to those of cumulated causes of encephalitis in the United States in these age categories. The case-fatality rate of CHIKV-associated encephalitis was 16.6% - the proportion of children discharged with persistent disabilities estimated between 30% - 45%. Beyond the neonatal period, the clinical presentation - outcomes were less severe in infants than in adults. In the context of a large outbreak, CHIKV is a significant cause of CNS disease. As with other etiologies, CHIKV-associated encephalitis case distribution by age follows a U-shaped parabolic curve.

Imprenta: Neurology, v. 86, n. 1, p. 94-102, 2016

Identificador do objeto digital: 10.1212/WNL.0000000000002234

Descritores: Chikungunya virus - Antibodies ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus

Data de publicação: 2016

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