Autor(es): Petersen Lyle R, Stramer Susan L, Powers Ann M

Resumo: In recent years, large chikungunya virus (CHIKV) outbreaks originating in Kenya have spread to isl-s of the Indian Ocean - parts of India, Southeast Asia, - Europe. Concern of transfusion transmission has been heightened for this mosquito-borne arbovirus because of high population infection incidence during outbreaks - the high-titer viremia lasting approximately 6 days. The virus has not circulated in the Americas; however, the abundant presence of competent mosquito vectors suggests large outbreaks are possible should the virus be introduced - autochthonous transmission occur. Chikungunya virus produces a fever-arthralgia syndrome resulting in considerable morbidity - some mortality, particularly among older age groups -/or those with pre-existing conditions. Estimated transfusion risks range as high as 150 per 10 000 donations during outbreaks. Possible measures to prevent possible CHIKV transfusion transmission include deferral of symptomatic donors, discontinuing blood collections in affected areas, - CHIKV nucleic acid screening of donations. Even a relatively small outbreak in Italy resulted in considerable adverse impact on blood collections - economic consequence. Assays suitable for testing donations for CHIKV RNA are not yet available, - given the highly geographically - temporally sporadic nature of CHIKV outbreaks, there may be considerable reluctance to develop - implement them.

Imprenta: Transfusion Medicine Reviews, v. 24, n. 1, p. 15-21, 2010

Identificador do objeto digital: 10.1016/j.tmrv.2009.09.002

Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Pathogenesis ; Chikungunya virus - RNA ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Public health

Data de publicação: 2010

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