Autor(es): Gasque Philippe, Couderc Therese,Lecuit Marc, Roques Pierre, Ng Lisa F P

Resumo: Chikungunya virus (CHIKV) is an arbovirus associated with acute - chronic arthralgia that re-emerged in the Indian Ocean isl-s in 2005-2006 - is currently responsible for the ongoing outbreaks in the Caribbean isl-s - the Americas. We describe here the acute - chronic clinical manifestations of CHIKV in patients that define the disease. We also review the various animal models that have been developed to study CHIKV infection - pathology - further strengthened the underst-ing of the cellular - molecular mechanisms of CHIKV infection - immunity. A complete underst-ing of the immunopathogenesis of CHIKV infection will help develop the needed preventive - therapeutic approaches to combat this arbovirosis.

Palavras-Chave: Adaptive immunity; Chikungunya; Cytokines and chemokines; Inflammation; Innate immunity; Target cells

Imprenta: Vector Borne and Zoonotic Diseases, v. 15, n. 4, p. 241-249, 2015

Identificador do objeto digital: 10.1089/vbz.2014.1710

Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Cell ; Chikungunya virus - Cytopathology ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Cytokines ; Chikungunya virus - Inflammation ; Chikungunya Virus - Virus

Data de publicação: 2015

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