Chikungunya virus nsP3 blocks stress granule assembly by recruitment of G3BP into cytoplasmic foci
Autor(es)Fros Jelke J, Domeradzka Natalia E, Baggen Jim, Geertsema Corinne, Flipse Jacky, Vlak Just M, Pijlman Gorben P
ResumoChikungunya virus nonstructural protein nsP3 has an essential but unknown role in alphavirus replication - interacts with Ras-GAP SH3 domain-binding protein (G3BP). Here we describe the first known function of nsP3, to inhibit stress granule assembly by recruiting G3BP into cytoplasmic foci. A conserved SH3 domain-binding motif in nsP3 is essential for both nsP3-G3BP interactions - viral RNA replication. This study reveals a novel role for nsP3 as a regulator of the cellular stress response.
ImprentaJournal of Virology, v. 86, n. 19, p. 10873-10879, 2012
Identificador do Objeto Digital10.1128/JVI.01506-12
DescritoresChikungunya virus - Biosynthesis ; Chikungunya virus - Cell ; Chikungunya virus - Molecular structure ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - RNA ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever
Data de Publicação:2012
