Chikungunya fever: epidemiology, clinical syndrome, pathogenesis and therapy
Autor(es): Thiberville Simon-Djamel, Moyen Nanikaly, Dupuis-Maguiraga Laurence, Nougairede Antoine, Gould Ernest A, Roques Pierre, de Lamballerie Xavier
Resumo: Chikungunya virus (CHIKV) is the aetiological agent of the mosquito-borne disease chikungunya fever, a debilitating arthritic disease that, during the past 7years, has caused immeasurable morbidity - some mortality in humans, including newborn babies, following its emergence - dispersal out of Africa to the Indian Ocean isl-s - Asia. Since the first reports of its existence in Africa in the 1950s, more than 1500 scientific publications on the different aspects of the disease - its causative agent have been produced. Analysis of these publications shows that, following a number of studies in the 1960s - 1970s, - in the absence of autochthonous cases in developed countries, the interest of the scientific community remained low. However, in 2005 chikungunya fever unexpectedly re-emerged in the form of devastating epidemics in - around the Indian Ocean. These outbreaks were associated with mutations in the viral genome that facilitated the replication of the virus in Aedes albopictus mosquitoes. Since then, nearly 1000 publications on chikungunya fever have been referenced in the PubMed database. This article provides a comprehensive review of chikungunya fever - CHIKV, including clinical data, epidemiological reports, therapeutic aspects - data relating to animal models for in vivo laboratory studies. It includes suplementary Tables of all WHO outbreak bulletins, ProMED Mail alerts, viral sequences available on GenBank, - PubMed reports of clinical cases - seroprevalence studies.
Palavras-Chave: Alphavirus; Antiviral therapy; Arbovirus; Chikungunya fever; Chikungunya virus
Imprenta: Antiviral Research, v. 99, n. 3, p. 345-370, 2013
Identificador do objeto digital: 10.1016/j.antiviral.2013.06.009
Descritores: Chikungunya virus - Arbovirus ; Chikungunya virus - Genome ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2013
