Applications of animal models of infectious arthritis in drug discovery: a focus on alphaviral disease
Autor(es): Herrero Lara, Nelson Michelle, Bettadapura Jayaram, Gahan Michelle E, Mahalingam Suresh
Resumo: Animal models, which mimic human disease, are invaluable tools for underst-ing the mechanisms of disease pathogenesis - development of treatment strategies. In particular, animal models play important roles in the area of infectious arthritis. Alphaviruses, including Ross River virus (RRV), o'nyong-nyong virus, chikungunya virus (CHIKV), mayaro virus, Semliki Forest virus - sindbis virus, are globally distributed - cause transient illness characterized by fever, rash, myalgia, arthralgia - arthritis in humans. Severe forms of the disease result in chronic incapacitating arthralgia - arthritis. The mechanisms of how these viruses cause musculoskeletal disease are ill defined. In recent years, the use of a mouse model for RRV-induced disease has assisted in unraveling the pathobiology of infection - in discovering novel drugs to ameliorate disease. RRV as an infection model has the potential to provide key insights into such disease processes, particularly as many viruses, other than alphaviruses, are known to cause infectious arthritides. The emergence - outbreak of CHIKV in many parts of the world has necessitated the need to develop animal models of CHIKV disease. The development of non-human primate models of CHIKV disease has given insights into viral tropism - disease pathogenesis - facilitated the development of new treatment strategies. This review highlights the application of animal models of alphaviral diseases in the fundamental underst-ing of the mechanisms that contribute to disease - for defining the role that the immune response may have on disease pathogenesis, with the view of providing the foundation for new treatments.
Palavras-Chave: Alphavirus; Animal models; Chemokines; Chikungunya virus; Cytokines; Macrophage; Ross River virus; Drug discovery; Infectious Arthritis; Inflammation
Imprenta: Current Drug Targets, v. 12, n. 7, p. 1024-1036, 2011
Identificador do objeto digital: 10.2174/138945011795677836
Descritores: Chikungunya virus - Immune response ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Immune response ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Inflammation ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever
Data de publicação: 2011
