Antigenic relationship between Chikungunya virus strains and o'nyong nyong virus using monoclonal antibodies
Autor(es): Blackburn N K, Besselaar T G, Gibson G
Resumo: Chikungunya (CHIK) strains from Africa - Asia were shown to be antigenically closely related using a panel of monoclonal antibodies (mAb) prepared against strains H817 from Africa - PhH15483 from Asia. The one-way antigenic relationship between CHIK - o'nyong nyong (ONN) viruses was demonstrated at the epitope level using the immunofluorescence - haemagglutination inhibition techniques. Results of tests with mAb against ONN virus suggest that, while ONN virus has retained most of the CHIK antigenic sites, many of the ONN epitopes have undergone sufficient conformational change such that mAbs prepared against them do not recognize sites on CHIK virus.
Palavras-Chave: Arbovirus; Chikungunya virus; O'nyong nyong virus; mAb; Epitopes; Antigenic relationship; Africa; Asia
Imprenta: Research in Virology, v. 146, n. 1, p. 69-73, 1995
Identificador do objeto digital: 10.1016/0923-2516(96)80591-7
Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Serology ; Chikungunya virus - Serology ; Chikungunya Virus - Virus ; Chikungunya virus - Immunology
Data de publicação: 1995
