Autor(es): Khatun Selina, Chakraborty Apurba, Rahman Mahmudur, Nasreen Banu Nuzhat, Rahman Mohammad Mostafizur, Hasan S M Murshid, Luby Stephen P, Gurley Emily S

Resumo: The first identified Chikungunya outbreak occurred in Bangladesh in 2008. In late October 2011, a local health official from Dohar Sub-district, Dhaka District, reported an outbreak of undiagnosed fever - joint pain. We investigated the outbreak to confirm the etiology, describe the clinical presentation, - identify associated vectors. During November 2-21, 2011, we conducted house-to-house surveys to identify suspected cases, defined as any inhabitant of Char Kushai village with fever followed by joint pain in the extremities with onset since August 15, 2011. We collected blood specimens - clinical histories from self-selected suspected cases using a structured questionnaire. Blood samples were tested for IgM antibodies against Chikungunya virus. The village was divided into nine segments - we collected mosquito larvae from water containers in seven r-omly selected houses in each segment. We calculated the Breteau index for the village - identified the mosquito species. The attack rate was 29% (1105/3840) - 29% of households surveyed had at least one suspected case: 15% had ?3. The attack rate was 38% (606/1589) in adult women - 25% in adult men (320/1287). Among the 1105 suspected case-patients, 245 self-selected for testing - 80% of those (196/245) had IgM antibodies. In addition to fever - joint pain, 76% (148/196) of confirmed cases had rash - 38%(75/196) had long-lasting joint pain. The village Breteau index was 35 per 100 - 89%(449/504) of hatched mosquitoes were Aedes albopictus. The evidence suggests that this outbreak was due to Chikungunya. The high attack rate suggests that the infection was new to this area, - the increased risk among adult women suggests that risk of transmission may have been higher around households. Chikungunya is an emerging infection in Bangladesh - current surveillance - prevention strategies are insufficient to mount an effective public health response.

Imprenta: PLoS Neglected Tropical Diseases, v. 9, n. 7, 2015

Identificador do objeto digital: 10.1371/journal.pntd.0003907

Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Antibodies ; Chikungunya virus - Infectious diseases ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health

Data de publicação: 2015

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