Acute Chikungunya and persistent musculoskeletal pain following the 2006 Indian epidemic: a 2-year prospective rural community study
Autor(es): Chopra A, Anuradha V, Ghorpade R, Saluja M
Resumo: Chikungunya virus (CHIKV) data from population studies are sparse. During the 2006 epidemic, 509 clinical cases (43% attack rate) were identified in a village survey (West India); laboratory investigations demonstrated normal blood cell counts, elevated acute-phase reactants [erythrocyte sedimentation rate, C-reactive protein - interleukin-6 (IL-6)] - excluded malaria - dengue. Acute CHIKV was characterized by high fever, severe peripheral polyarthralgias, axial myalgias - intense fatigue in over 90% of cases; skin rash (34%) - headache (19%) were uncommon. There were 49% - 62% of survey cases seropositive for IgM (rapid assay) - IgG (immunofluorescence) anti-CHIKV antibodies, respectively. Sixty-five percent of cases recovered within 4 weeks. None of the cases died. Of the population, 4·1% - 1·6% suffered from persistent rheumatic pains, predominantly non-specific, at 1 - 2 years, respectively. Chronic inflammatory arthritis was uncommon (0·3% at 1 year) although serum IL-6 often remained elevated in chronic cases. A larger population study is required to describe post-CHIKV rheumatism - its prognosis.
Palavras-Chave: Arthritis; Chikungunya; Epidemic; Musculoskeletal; Rheumatism
Imprenta: Epidemiology and Infection, v. 140, n. 5, p. 842-850, 2012
Identificador do objeto digital: 10.1017/S0950268811001300
Descritores: Chikungunya virus - Cell ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Cytokines ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2012
