A226V mutation in virus during the 2007 chikungunya outbreak in Kerala, India
Autor(es): Kumar N Pradeep, Joseph Rajan, Kamaraj T, Jambulingam P
Resumo: Kerala State in India was gripped by a renewed - widespread outbreak of Chikungunya virus (CHIKV) infection during 2007. Here, we report the A226V mutation in the glycoprotein envelope 1 (E1) gene of the virus among isolates collected from the three worst-affected districts of the state during this outbreak. This mutation had already been suggested to be directly responsible for a significant increase in CHIKV infectivity in Aedes albopictus. The badly affected districts in Kerala State during 2007 have abundant rubber plantations, which supported prolific breeding of Ae. albopictus mosquitoes. The abundance of Ae. albopictus in the region - molecular evolution of CHIKV may be contributing factors for the renewed epidemic of chikungunya fever during 2007.
Imprenta: The Journal of General Virology, v. 89, Pt 8, p. 1945-1948, 2008
Identificador do objeto digital: 10.1099/vir.0.83628-0
Descritores: Chikungunya virus - DNA ; Chikungunya virus - Molecular structure ; Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Transmission ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Epidemic ; Chikungunya virus - Epidemiology ; Chikungunya virus - Public health
Data de publicação: 2008
