A meta-analysis of the diagnostic accuracy of dengue virus-specific IgA antibody-based tests for detection of dengue infection
Autor(es): Alagarasu K, Walimbe A M, Jadhav S M, Deoshatwar A R
Resumo: Immunoglobulin A (IgA)-based tests have been evaluated in different studies for their utility in diagnosing dengue infections. In most of the studies, the results were inconclusive because of a small sample size. Hence, a meta-analysis involving nine studies with 2096 samples was performed to assess the diagnostic accuracy of IgA-based tests in diagnosing dengue infections. The analysis was conducted using Meta-Disc software. The results revealed that IgA-based tests had an overall sensitivity, specificity, diagnostic odds ratio, - positive - negative likelihood ratios of 73·9%, 95·2%, 66·7, 22·0 - 0·25, respectively. Significant heterogeneity was observed between the studies. The type of test, infection status - day of sample collection influenced the diagnostic accuracy. The IgA-based diagnostic tests showed a greater accuracy when the samples were collected 4 days after onset of symptoms - for secondary infections. The results suggested that IgA-based tests had a moderate level of accuracy - are diagnostic of the disease. However, negative results cannot be used alone for dengue diagnosis. More prospective studies comparing the diagnostic accuracy of combinations of antigen-based tests with either IgA or IgM are needed - might be useful for suggesting the best strategy for dengue diagnosis.
Palavras-Chave: Dengue fever; IgA; Dengue haemorrhagic fever; Immunology; Meta-analysis
Imprenta: Epidemiology and Infection, v. 144, n. 4, p. 876-886, 2016
Identificador do objeto digital: 10.1017/S0950268815001922
Descritores: Chikungunya Virus - Virus ; Chikungunya virus - Chikungunya fever ; Chikungunya virus - Dengue ; Chikungunya virus - Epidemiology ; Chikungunya virus - Immunology
Data de publicação: 2016
