Autor(es): Wang Danher, Suhrbier Andreas, Penn-Nicholson Adam, Woraratanadharm Jan, Gardner Joy, Luo Min, Le Thuy T, Anraku Itaru, Sakalian Michael, Einfeld David, Dong John Y

Resumo: Chikungunya virus, a mosquito-borne alphavirus, recently caused the largest epidemic ever seen for this virus. Chikungunya disease primarily manifests as a painful - debilitating arthralgia/arthritis, - no effective drug or vaccine is currently available. Here we describe a recombinant chikungunya virus vaccine comprising a non-replicating complex adenovirus vector encoding the structural polyprotein cassette of chikungunya virus. A single immunisation with this vaccine consistently induced high titres of anti-chikungunya virus antibodies that neutralised both an old Asian isolate - a Réunion Isl- isolate from the recent epidemic. The vaccine also completely protected mice against viraemia - arthritic disease caused by both virus isolates.

Palavras-Chave: Chikungunya; Adenovirus; Vaccine; Arthritis

Imprenta: Vaccine, v. 29, n. 15, p. 2803-2809, 2011

Identificador do Objeto Digital: 10.1016/j.vaccine.2011.01.108

Descritores: Chikungunya virus - Pathogenesis ; Chikungunya virus - Proteins ; Chikungunya virus - Antibodies ; Chikungunya virus - Inflammation ; Chikungunya virus - Viral infections ; Chikungunya Virus - Virus ; Chikungunya virus - Vaccine ; Chikungunya virus - Epidemic ; Chikungunya virus - Immunology ; Chikungunya virus - Public health

Data de Publicação: 2011