Major essential oils composition and immunotoxicity activity from leaves of Foeniculum vulgare against Aedes aegypti L
Autor(es): Chung, I. M.; Ro, H. M.; Moon, H. I.
Resumo: The leaves of Foeniculum vulgare (Umbelliferae) were extracted and the major essential oil composition and immunotoxicity effects were studied. The analyses conducted by gas chromatography and mass spectroscopy (GC-MS) revealed the essential oils of F. vulgare leaves. The F. vulgare essential oil yield was 0.97%, and GC/MS analysis revealed that its major constituents were methyl clavicol (46.3%), alpha -phellandrene (18.2%), fenchone (10.6%), (E)-anethole (11.3%), myrcene (3.4%), and alpha -pinene (2.1%). The essential oil had a significant toxic effect against early fourth-stage larvae of Aedes aegypti L with an LC sub(50) value of 41.23 ppm and an LC sub(90) value of 65.24 ppm. Also, methyl clavicol ( greater than or equal to 98.0%), alpha -phellandrene ( greater than or equal to 95.0%), fenchone ( greater than or equal to 98.0%), (E)-anethole ( greater than or equal to 99.0%), myrcene ( greater than or equal to 99.0%), and alpha -pinene ( greater than or equal to 99.0%) were tested against the F sub(2) laboratory strain of A. aegypti. Fenchone ( greater than or equal to 98.0%) and (E)-anethole ( greater than or equal to 99.0%) have medium activity with an LC sub(50) value of 73.11 ppm and 102.41 ppm. The above data indicate that major compounds interaction may play a more important role in the toxicity of essential oil.
Palavras-Chave: Toxicity; Major constituents; Aquatic insects; Mortality causes; Immunotoxicity; Gas chromatography; Larvae; Leaves; Essential oils; Myrcene; Foeniculum vulgare; Aedes aegypti
Imprenta: Immunopharmacology and Immunotoxicology, v. 33, n. 3, p. 450-453, 2011.
Descritores: Aedes aegypti - Immune response ; Aedes aegypti - Immunology
Data de publicação: 2011
