Molecular Cloning and Expression of Several New Anopheles cracens Epsilon Class Glutathione Transferases
Autor(es): Wongtrakul, Jeerang; Wongsantichon, Jantana; Vararattanavech, Ardcharaporn; Leelapat, Posri; Prapanthadara, La-aied; Ketterman, Albert J.
Resumo: Glutathione transferases, GSTs, are detoxification proteins that are found in most organisms. The acGSTE3-3 had the ability to conjugate 4-hydroxynonenal, a cytotoxic lipid peroxidation product. Although other Epsilon GSTs showed roles in insecticide metabolism, the acGSTE3-3 appeared to have a major role in detoxifying lipid peroxidation products conferring protection against oxidative damage.
Palavras-Chave: Glutathione Transferase; An. Cracens; Epsilon Class; 4-HNE; Lipid Peroxidation; Oxidative Stress
Imprenta: Protein and Peptide Letters, v. 16, n. 1, p. 75-81, 2009
Descritores: Aedes aegypti - Proteins
Data de publicação: 2009
