Investigation of inclusion complexes of citronella oil, citronellal and citronellol with beta-cyclodextrin for mosquito repellent
Autor(es): Songkro, Sarunyoo; Hayook, Narissara; Jaisawang, Jittarat; Maneenuan, Duangkhae; Chuchome, Thitima; Kaewnopparat, Nattha
Resumo: The aim of this study was to prepare the inclusion complexes of citronella oil, citronellal or citronellol with beta-cyclodextrin and evaluate their physicochemical properties using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). A kneading method was employed to prepare the inclusion complexes and weight ratios of each of the active substance to beta-cyclodextrin were 1:1 (1:1 CPX) and 1:2 (1:2 CPX). For comparison purposes, physical mixtures of these active compounds and beta-cyclodextrin were also prepared and investigated. Unlike the physical mixtures, the SEM technique revealed drastic changes in the shapes and morphologies of the particles for the inclusion complexes. Furthermore, the FTIR and DSC results seemed to reveal some interactions between the active substance and beta-cyclodextrin. The o/w lotions, which contained 10% w/w citronella oil (normal citronella oil; 1:1 CPX or 1:2 CPX), were formulated using Cremophors as emulsifiers. With modified Franz diffusion cell and synthetic membrane, the release rates of citronella oil from the lotions containing the inclusion complexes were significantly lower than that from the prepared lotion containing normal citronella oil. The mosquito (Aedes aegypti) repellent efficacy of the lotions containing citronella oil, citronellal or citronellol (both normal and inclusion complexes) was further evaluated by human-bait technique. The highest mosquito repellent activity was observed in the formulation which contained citronella oil-beta-cyclodextrin inclusion complex at weight ratio of 1:1.
Palavras-Chave: Citronella oil; Citronellal; Citronellol; beta-Cyclodextrin; Inclusion complex; Mosquito repellent
Imprenta: Journal of Inclusion Phenomena and Macrocyclic Chemistry, v. 72, n. 42463, p. 339-355, 2012
Identificador do objeto digital: 10.1007/s10847-011-9985-7
Descritores: Aedes aegypti - Repellent
Data de publicação: 2012
