Computational selections of terpenes present in the plant Calotropis gigantea as mosquito larvicide's by blocking the sterol carrying protein, AeSCP-2
Autor(es): Kumar, P. Suresh; Chezhian, A.; Raja, P. Senthil; Sathiyapriya, J.
Resumo: The present study reports the phytochemical properties of Calotropis gigantea (Asclepiadaceae) commonly known as milk weed. In addition, in silico docking analysis was also carried out to assess the mosquito larvicidal potential of three terpene compounds isolated from C. gigantea. Considerable amount of primary metabolites, essential macro and micro nutrients were documented in the plant. The GC-MS analysis of the chloroform extract revealed the presence of eight terpenes in the plant. From the docking studies it is evident that a-amyrin has a great potential against AeSCP-2. The phytochemical screening and docking results gives strong baseline information for the posterity.
Palavras-Chave: Calotropis gigantea; Phytochemical; Terpenes; Mosquito larvicidal
Imprenta: Bangladesh Journal of Pharmacology, v. 7, n. 1, p. 1-5, 2012
Identificador do objeto digital: 10.3329/bjp.v7i1.8414
Descritores: Aedes aegypti - Larvicide ; Aedes aegypti - Molecular screening
Data de publicação: 2012
