Autor(es): Ham, P. J.; Phiri, J. S.; Nolan, G. P.

Resumo: Two strains of Aedes aegypti , differing in their susceptibility to Brugia pahangi , were examined with regard to the effect on the proportion of microfilariae migrating from the mid-gut, of specific carbohydrate supplements in the infecting bloodmeal. N-Acetyl-D-glucosamine (GlcNAc), a sugar also present on the microfilarial sheath, significantly increased the migration rate. This enhancement is greater for the refractory strain of Ae. aegypti . The use of sucrose as a control sugar results in no enhancement of microfilariae migration. It is postulated that the GlcNAc is acting by blocking endogenous gut/peritrophic membrane carbohydrate binding proteins, which would normally inhibit microfilariae migration. Furthermore, there is a significant correlation whereby increasing loads of microfilariae ingested result in decreasing proportions migrating across the mid-gut.

Palavras-Chave: Migrations; Parasites; Parasite resistance; Carbohydrates; Aquatic insects; Migration; Hemocoel; Filariasis; Aedes aegypti; Brugia pahangi; Culicidae; Diptera

Imprenta: Medical and Veterinary Entomology, v. 5, n. 4, p. 485-493, 1991.

Descritores: Aedes aegypti - Proteins

Data de publicação: 1991