Zika virus infection of the central nervous system of mice
Autor(es): Bell T.M., Field E.J., Narang H.K.
Resumo: Intracerebral inoculation of newborn and5-week-old mice with Zika virus resulted in an early and marked enlargement of astroglial cells with patchy destruction of the pyriform cells of Ammon's horn. Replication of the virus was demonstrated in both neurones and astroglial cells. New virions appeared to be formed within networks of endoplasmic reticulum. The similarity of these ultrastructural observations to those obtained from in vivo studies of other group B arboviruses is contrasted with the widely differing findings from in vitro studies. © 1971 Springer-Verlag.
Palavras-Chave: Ammonium Derivative; Antiserum; Bromide; Animal; Arbovirus; Article; Central Nervous System; Electron Microscopy; Endoplasmic Reticulum; Glia; Growth, Development And Aging; Haplorhini; Hippocampus; Histology; Immunology; Isolation And Purification; Kidney; Macaca; Microbiology; Mouse; Mouse Strain; Nerve Cell; Pathology; Serodiagnosis; Virus Culture; Virus Inclusion; Virus Infection; Virus Replication; Ammonium Compounds; Animal; Arbovirus Infections; Arboviruses; Bromides; Central Nervous System; Endoplasmic Reticulum; Haplorhini; Hippocampus; Histological Techniques; Immune Sera; Inclusion Bodies, Viral; Kidney; Macaca; Mice; Mice, Inbred Strains; Microscopy, Electron; Neuroglia; Neurons; Neutralization Tests; Virus Cultivation; Virus Replication
Imprenta: Archiv für die gesamte Virusforschung, v. 35, n.2-3, p. 183-193, 1971.
Descritores: Zika virus - Arboviruses ; Zika virus - Cells ; Zika virus - Immunology ; Zika virus - Viral infections
Data de publicação: 1971
