Autor(es): Baba S.S., Fagbami A.H., Olaleye O.D.

Resumo: The antigenic relationship of 9 flaviviruses, Yellow fever (YF), Wesselsbron (WSL), Uganda S (UGS), Potiskum (POT), West Nile (WN), Banzi (BAN), Zika (ZK), Dengue type 1 (DEN-1) and Dengue type 2 (DEN-2), was assessed by cross-haemagglutination-inhibition (Cross-HI) and cross-complement fixation (Cross-CF) reactions between each of the viruses and their homologous immune mouse ascitic fluids. Titre ratios were calculated using the heterologous and homologous titres. Cross-CF reactions revealed wider antigenic variations among viruses than Cross-HI reactions. There was no significant antigenic variation between WSL, POT and YF viruses using either of those methods. However, definite differences in antigenicity were observed between them and UGS, BAN and ZK viruses. There were no significant differences between UGS, BAN and ZK or between DEN-1 and DEN-2. The serological relationship among flaviviruses is important in establishing diagnosis and epidemiology of these infections in Africa.

Palavras-Chave: antigenic variation, ascites fluid, Flavivirus

Imprenta: Revista do Instituto de Medicina Tropical de São Paulo, v. 40, n. 6, p. 343-349, nov-dec. 1998

Descritores: Zika virus - Antigenic variation ; Zika virus - Immunology ; Zika virus - Serological diagnosis ; Zika virus - Epidemiology ; Zika virus - Zika fever

Data de publicação: 1998

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