Prophylaxis and treatment of thromboembolic diseases during pregnancy with dalteparin.

Autor(es): Rey E; Rivard G E

Resumo: To determine if a prophylactic dose of dalteparin, 5000 IU daily, and if the adjusted-weight dalteparin therapeutic dose of 100 IU/kg twice daily are appropriate in pregnancy. Anti-Xa activity levels were used to assess prophylactic (33 women) and therapeutic (15 women) dalteparin dosage throughout pregnancy. Analysis of variance was used and P-values less than 0.05 were considered statistically significant. In the prophylactic group, anti-Xa activity levels did not vary significantly throughout pregnancy (P=0.15). The initial dalteparin dose was modified on the first anti-Xa activity measurement in eight women, whose weight was statistically different from those remaining on the initial dose (P<0.001). The adjusted-weight therapeutic dalteparin dose induced adequate anti-Xa activity levels. Dalteparin, 5000 IU daily, is suitable for most pregnant women and does not need to be modified in the third trimester. A therapeutic dalteparin dose adjusted according to pregnancy weight is appropriate.

Palavras-Chave: Pregnancy; Dalteparin; Anticoagulation

Imprenta: International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics, v. 71, n. 1, p. 19-24, 2000

Identificador do objeto digital: 10.1016/S0020-7292(00)00290-3

Descritores: Aedes aegypti - Proteins ; Aedes aegypti - Clinical examination ; Aedes aegypti - Public health

Data de publicação: 2000