Oligomerization of Cry11Aa from Bacillus thuringiensis has an important role in toxicity against Aedes aegypti.
Autor(es): Mu??oz-Garay Carlos; Rodr?guez-Almaz?!n Claudia; Aguilar Jose N; Portugal Leivi; G?³mez Isabel; Saab-Rincon Gloria; Sober?³n Mario; Bravo Alejandra
Resumo: Cry11Aa and Cyt1Aa of Bacillus thuringiensis are active against mosquitoes and show synergism. Cyt1Aa functions as a membrane receptor inducing Cry11Aa oligomerization. Here we characterized Cry11Aa helix alpha-3 mutants impaired in oligomerization and toxicity against Aedes aegypti, indicating that oligomerization of Cry11Aa is important for toxin action. Cyt1Aa did not recover the insecticidal activity of Cry11Aa mutants.
Imprenta: Applied and Environmental Microbiology, v. 75, n. 23, p. 7548-7550, 2009
Identificador do objeto digital: 10.1128/AEM.01303-09
Descritores: Aedes aegypti - Pathogenesis ; Aedes aegypti - Proteins
Data de publicação: 2009
