New enamine derivatives of lapachol and biological activity.

Autor(es): Oliveira Mailcar F; Lemos Telma G; de Mattos Marcos C; Segundo Taciana A; Santiago Gilvandete M P; Braz-Filho Raimundo

Resumo: A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells.

Palavras-Chave: Lapachol; Enamine derivatives; Biological activities.

Imprenta: Anais da Academia Brasileira de Cie?ncias, v. 74, n. 2, p. 211-221, 2002

Identificador do objeto digital: 10.1590/S0001-37652002000200004

Descritores: Aedes aegypti - Cell

Data de publicação: 2002