IgE and IgG4 antibody responses to Aedes saliva in African children.

Autor(es): Remoue Franck; Alix Eric; Cornelie Sylvie; Sokhna Cheikh; Cisse Badara; Doucoure Souleymane; Mouchet François; Boulanger Denis; Simondon François

Resumo: Aedes mosquitoes are the major vectors of (re)-emerging infections including arboviruses (dengue, Chikungunya, yellow fever) in developing countries. Moreover, the emergence of Aedes-borne diseases in the developed world is currently a source of concern. Evaluation of human immune responses to Aedes bites could be a useful immuno-epidemiological tool for evaluating exposure to Aedes-borne diseases and thus predicting the risk of such emerging diseases. Specific IgE and IgG4 antibody (Ab) responses to Aedes aegypti saliva were evaluated in young Senegalese children living in an area of exposure to the Aedes vector. Specific IgE and IgG4 responses increased during rainy season of high exposure to Aedes bites. In addition, the evolution of anti-saliva isotype levels during the rainy season presented spatial heterogeneity between the studied villages. These preliminaries results support the potential approach of using anti-saliva Ab responses for evaluating exposure to Aedes vectors and risks of emerging arbovirus infections.

Palavras-Chave: Aedes; Antibody response; Saliva; Biomarker; Vector-borne disease

Imprenta: Acta Tropica, v. 104, n. 2-3, p. 108-115, 2007

Identificador do objeto digital: https://doi.org/10.1016/j.actatropica.2007.07.011

Descritores: Aedes aegypti - Arbovirus ; Aedes aegypti - Pathogenesis ; Aedes aegypti - Proteins ; Aedes aegypti - Antibodies ; Aedes aegypti - Viral infections ; Aedes aegypti - Transmission ; Aedes aegypti - Chikungunya Fever ; Aedes aegypti - Dengue ; Aedes aegypti - Immunology ; Aedes aegypti - Public health

Data de publicação: 2007