Households as foci for dengue transmission in highly urban Vietnam.

Autor(es): Anders Katherine L; Nga Le Hong; Thuy Nguyen Thi Van; Ngoc Tran Van; Tam Cao Thi; Tai Luong Thi Hue; Truong Nguyen Thanh; Duyen Huynh Thi Le; Trung Vu Tuan; Kien Duong Thi Hue; Wolbers Marcel; Wills Bridget; Chau Nguyen Van Vinh; Tho Nguyen Dac; Simmons Cameron P

Resumo: Dengue control programs commonly employ reactive insecticide spraying around houses of reported cases, with the assumption that most dengue virus (DENV) transmission occurs in the home. Focal household transmission has been demonstrated in rural settings, but it is unclear whether this holds true in dense and mobile urban populations. We conducted a prospective study of dengue clustering around households in highly urban Ho Chi Minh City, Vietnam. We enrolled 71 index cases with suspected dengue (subsequently classified as 52 dengue cases and 19 non-dengue controls); each initiated the enrollment of a cluster of 25-35 household members and neighbors who were followed up over 14 days. Incident DENV infections in cluster participants were identified by RT-PCR, NS1-ELISA, and/or DENV-IgM/-IgG seroconversion, and recent infections by DENV-IgM positivity at baseline. There was no excess risk of DENV infection within dengue case clusters during the two-week follow-up, compared to control clusters, but the prevalence of recent DENV infection at baseline was two-fold higher in case clusters than controls (OR 2.3, 95%CI 1.0-5.1, p = 0.05). Prevalence of DENV infection in Aedes aegypti was similar in case and control houses, and low overall (1%). Our findings are broadly consistent with household clustering of dengue risk, but indicate that any clustering is at a short temporal scale rather than sustained chains of localized transmission. This suggests that reactive perifocal insecticide spraying may have a limited impact in this setting.

Imprenta: PLoS Neglected Tropical Diseases, v. 9, n. 2, 2015

Identificador do objeto digital: 10.1371/journal.pone.0138082.

Descritores: Aedes aegypti - Flaviviridae ; Aedes aegypti - Pathogenesis ; Aedes aegypti - Viral infections ; Aedes aegypti - RT-PCR ; Aedes aegypti - Virus ; Aedes aegypti - Transmission ; Aedes aegypti - Dengue ; Aedes aegypti - Epidemiology ; Aedes aegypti - Immunology ; Aedes aegypti - Public health

Data de publicação: 2015