Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes.

Autor(es): Nguyet Minh Nguyen; Duong Thi Hue Kien; Trung Vu Tuan; Nguyen Than Ha Quyen; Tran Chau N B; Long Vo Thi; Dui Le Thi; Nguyen Hoa Lan; Farrar Jeremy J; Holmes Edward C; Rabaa Maia A; Bryant Juliet E; Nguyen Truong Thanh; Nguyen Huong Thi Cam; Nguyen Lan Thi Hong; Pham Mai Phuong; Nguyen Hung The; Luong Tai Thi Hue; Wills Bridget; Nguyen Chau Van Vinh; Wolbers Marcel; Simmons Cameron P

Resumo: Dengue is the most prevalent arboviral disease of humans. The host and virus variables associated with dengue virus (DENV) transmission from symptomatic dengue cases (n = 208) to Aedes aegypti mosquitoes during 407 independent exposure events was defined. The 50% mosquito infectious dose for each of DENV-1-4 ranged from 6.29 to 7.52 log10 RNA copies/mL of plasma. Increasing day of illness, declining viremia, and rising antibody titers were independently associated with reduced risk of DENV transmission. High early DENV plasma viremia levels in patients were a marker of the duration of human infectiousness, and blood meals containing high concentrations of DENV were positively associated with the prevalence of infectious mosquitoes 14 d after blood feeding. Ambulatory dengue cases had lower viremia levels compared with hospitalized dengue cases but nonetheless at levels predicted to be infectious to mosquitoes. These data define serotype-specific viremia levels that vaccines or drugs must inhibit to prevent DENV transmission.

Imprenta: Proceedings of the National Academy of Sciences of the United States of America, v. 110, n. 22, p. 9072-9077, 2013

Identificador do objeto digital: 10.1073/pnas.1303395110.

Descritores: Aedes aegypti - DNA ; Aedes aegypti - Flaviviridae ; Aedes aegypti - Molecular Structure ; Aedes aegypti - Pathogenesis ; Aedes aegypti - RNA ; Aedes aegypti - Inflammation ; Aedes aegypti - Viral infections ; Aedes aegypti - RT-PCR ; Aedes aegypti - Virus ; Aedes aegypti - Transmission ; Aedes aegypti - Vaccine ; Aedes aegypti - Dengue ; Aedes aegypti - Epidemiology ; Aedes aegypti - Public health

Data de publicação: 2013