Autor(es)Nguyet Minh Nguyen; Duong Thi Hue Kien; Trung Vu Tuan; Nguyen Than Ha Quyen; Tran Chau N B; Long Vo Thi; Dui Le Thi; Nguyen Hoa Lan; Farrar Jeremy J; Holmes Edward C; Rabaa Maia A; Bryant Juliet E; Nguyen Truong Thanh; Nguyen Huong Thi Cam; Nguyen Lan Thi Hong; Pham Mai Phuong; Nguyen Hung The; Luong Tai Thi Hue; Wills Bridget; Nguyen Chau Van Vinh; Wolbers Marcel; Simmons Cameron P

ResumoDengue is the most prevalent arboviral disease of humans. The host and virus variables associated with dengue virus (DENV) transmission from symptomatic dengue cases (n = 208) to Aedes aegypti mosquitoes during 407 independent exposure events was defined. The 50% mosquito infectious dose for each of DENV-1-4 ranged from 6.29 to 7.52 log10 RNA copies/mL of plasma. Increasing day of illness, declining viremia, and rising antibody titers were independently associated with reduced risk of DENV transmission. High early DENV plasma viremia levels in patients were a marker of the duration of human infectiousness, and blood meals containing high concentrations of DENV were positively associated with the prevalence of infectious mosquitoes 14 d after blood feeding. Ambulatory dengue cases had lower viremia levels compared with hospitalized dengue cases but nonetheless at levels predicted to be infectious to mosquitoes. These data define serotype-specific viremia levels that vaccines or drugs must inhibit to prevent DENV transmission.

ImprentaProceedings of the National Academy of Sciences of the United States of America, v. 110, n. 22, p. 9072-9077, 2013

DescritoresAedes aegypti - DNA ; Aedes aegypti - Flaviviridae ; Aedes aegypti - Molecular Structure ; Aedes aegypti - Pathogenesis ; Aedes aegypti - RNA ; Aedes aegypti - Inflammation ; Aedes aegypti - Viral infections ; Aedes aegypti - RT-PCR ; Aedes aegypti - Virus ; Aedes aegypti - Transmission ; Aedes aegypti - Vaccine ; Aedes aegypti - Dengue ; Aedes aegypti - Epidemiology ; Aedes aegypti - Public health

Data de Publicação:2013