Female-specific flightless phenotype for mosquito control.

Autor(es): Fu Guoliang; Lees Rosemary S; Nimmo Derric; Aw Diane; Jin Li; Gray Pam; Berendonk Thomas U; White-Cooper Helen; Scaife Sarah; Kim Phuc Hoang; Marinotti Osvaldo; Jasinskiene Nijole; James Anthony A; Alphey Luke

Resumo: Dengue and dengue hemorrhagic fever are increasing public health problems with an estimated 50-100 million new infections each year. Aedes aegypti is the major vector of dengue viruses in its range and control of this mosquito would reduce significantly human morbidity and mortality. Present mosquito control methods are not sufficiently effective and new approaches are needed urgently. A sterile-male-release" strategy based on the release of mosquitoes carrying a conditional dominant lethal gene is an attractive new control methodology. Transgenic strains of Aedes aegypti were engineered to have a repressible female-specific flightless phenotype using either two separate transgenes or a single transgene, based on the use of a female-specific indirect flight muscle promoter from the Aedes aegypti Actin-4 gene. These strains eliminate the need for sterilization by irradiation, permit male-only release ("genetic sexing"), and enable the release of eggs instead of adults. Furthermore, these strains are expected to facilitate area-wide control or elimination of dengue if adopted as part of an integrated pest management strategy."

Palavras-Chave: Aedes aegypti; Dengue virus; Sterile insect technique; Genetic control; Population suppression

Imprenta: Proceedings of the National Academy of Sciences of the United States of America, v. 107, n. 10, p. 4550-4504, 2010

Identificador do objeto digital: https://doi.org/10.1073/pnas.1000251107

Descritores: Aedes aegypti - Flaviviridae ; Aedes aegypti - Genome ; Aedes aegypti - Molecular Structure ; Aedes aegypti - Pathogenesis ; Aedes aegypti - Proteins ; Aedes aegypti - Viral infections ; Aedes aegypti - virus ; Aedes aegypti - Transmission ; Aedes aegypti - Dengue ; Aedes aegypti - Public health

Data de publicação: 2010