Guillain-Barré syndrome in Spain, 1985-1997: epidemiological and public health views.

Autor(es): Cuadrado J I.; de Pedro-Cuesta J.; Ara J. R.; Cemillán C A.; Díaz M.; Duarte J.; Fernández M D.; Fernández O.; García-López F.; García-Merino A.; García-Montero R.; Martínez-Matos J. A.; Palomo F.; Pardo J.; Tobías A

Resumo: Retrospective demographic information and hospital record data were collected for 337 patients resident in Spain who had validated Guillain-Barré syndrome (GBS) diagnoses and clinical onset during the period 1985-1997 and had been admitted to 11 centres, covering a population of 3.9 million. The European age-adjusted GBS incidence per 100,000 for 1985-1997 among the population aged 20 and over was 0.85, with a breakdown of 1.14 in men and 0.58 in women. Incidence increased with age and time, with occasional rises that mimicked outbreaks and occurred at irregular 2- to 4-year intervals, mainly in winter. Spatial variation was modest. Respiratory and gastrointestinal infections respectively constituted 49.3 and 19.3% of recorded preceding events. The 97.5% intercentile limit, obtained from the 1985-1997 monthly incidences using predictions from a Poisson model, was proposed as the threshold value for pilot epidemiological surveillance of GBS in 1998-1999.

Imprenta: European Neurology, v. 46, n. 2, p. 83-91, 2001

Identificador do objeto digital: 10.1159/000050769

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Epidemiology ; Guillain-Barre Syndrome - Public health

Data de publicação: 2001