Free radical toxicity and antioxidants in Guillain-Barre syndrome, a preliminary study.

Autor(es): Kumar Kiran T.; Chandrika A.; Sumanth Krishna N.; Sireesha P; Rao Suryanarayana; Rao Anjali

Resumo: The generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of a vast array of disease processes including some neurological disorders. Ten patients with Guillain-Barre syndrome (GBS) and 10 age and sex-matched controls were included in this study. The erythrocyte glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA) levels, as well as plasma antioxidant vitamins C and E and serum glutathione-S-transferase (GST) levels were estimated spectrophotometrically. The plasma vitamin E and the serum total glutathione-S-transferase levels were markedly increased in both pre- and post-treated cases of GBS when compared to controls. The erythrocyte glutathione and malondialdehyde levels were significantly reduced in GBS cases when compared to normals. However, plasma vitamin C and erythrocyte superoxide dismutase were not altered when compared to controls. Free radical toxicity may have an influence in patients suffering from GBS.

Imprenta: Clinica Chimica Acta; International Journal of Clinical Chemistry, v. 346, n. 2, p. 205-209, 2004

Identificador do objeto digital: 10.1016/j.cccn.2004.03.032

Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Biochemistry ; Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Public health

Data de publicação: 2004