Emergence and clinical insights into the pathology of Chikungunya virus infection.

Autor(es): Jaffar-Bandjee Marie Christine; Ramful Duksha; Gauzere Bernard Alex; Hoarau Jean Jacques; Krejbich-Trotot Pascale; Robin Stephanie; Ribera Anne; Selambarom Jimmy; Gasque Philippe

Resumo: Major epidemics of Chikungunya have re-emerged with millions of cases worldwide. What was once largely a tropical disease in poorer countries is now recognized as a major global health issue. The disease is perpetuated by the alphavirus Chikungunya, and is transmitted by Aedes mosquitoes. The infection is highly symptomatic, with fever, skin rash and incapacitating arthralgia, which can evolve to chronic arthritis and rheumatism in elderly patients. Mother-to-child transmission, encephalitis, Guillain-Barré syndrome and deaths have been noted. In this article, we will highlight the epidemiological, clinical, virological and immunological aspects of the disease and mention the therapies that have been used during recent epidemics. Novel prevention measures to control the mosquito and a new vaccine are highly warranted.

Imprenta: Expert Review of Anti-infective Therapy, v. 8, n. 9, p. 987-996, 2010

Identificador do objeto digital: 10.1586/eri.10.92

Descritores: Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Infectious diseases ; Guillain-Barre Syndrome - Viral infections ; Guillain-Barre Syndrome - Virus ; Guillain-Barre Syndrome - Transmission ; Guillain-Barre Syndrome - Vaccine ; Guillain-Barre Syndrome - Chikungunya Fever ; Guillain-Barre Syndrome - Epidemic ; Guillain-Barre Syndrome - Epidemiology ; Guillain-Barre Syndrome - Public health

Data de publicação: 2010