Elevated number of cells secreting transforming growth factor beta in Guillain-Barré syndrome.

Autor(es): Dahle C.; Kvarnstrom M.; Ekerfelt C.; Samuelsson M.; Ernerudh J.

Resumo: We used ELISPOT and cell ELISA to study secretion of IL-4, IFN-gamma, TGF-beta, IL-6, and TNF-alpha by circulating mononuclear cells during the course of Guillain-Barré syndrome (GBS). Compared to healthy controls, patients with GBS had higher numbers of TGF-beta-secreting cells and the number of individuals with myelin-peptide-induced IL-4 and TGF-beta secretion was higher in the GBS group. No significant differences were seen concerning the predominantly pro-inflammatory cytokines IFN-gamma, IL-6 or TNF-alpha. Our findings indicate a down-regulatory role for TGF-beta and IL-4 in GBS.

Imprenta: Acta Pathologica, Microbiologica, et Immunologica Scandinavica, v. 111, n. 12, p. 1095-1104, 2003

Identificador do objeto digital: 10.1111/j.1600-0463.2003.apm1111204.x

Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Cytokines ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2003